Cristine L. Czachowski, Ph.D.
Associate Professor, Psychology
Area Head, Addiction Neuroscience Graduate Program
Director, NIAAA T32 Training Grant
B.S., Rutgers University (1989)
M.A., University of California, Santa Barbara (1994)
Ph.D., University of California, Santa Barbara (1998)
Neurobehavioral Assessment of Ethanol Seeking and Intake in the Rat.
My research uses an animal model to better understand the processes by which humans regulate alcohol consumption. Currently, I am working with a model that closely approximates human alcohol-drinking: from the onset of a "drinking episode" which starts with the purchase of a bottle or the entering of a bar, to the termination of that particular drinking binge. The ability to separate the seeking phase of alcohol-directed behavior from alcohol intake translates into an ability to identify treatments of alcohol abuse that can target alcohol craving before a person engages in drinking and essentially succumbs to "falling off the wagon". I am using this model to assess both drug treatments and basic neuroanatomically active agents to characterize the pharmacology and neural circuitry of alcohol reinforcement. More recently, I have incorporated the use of selectively bred ethanol-preferring rats as well as the examination of putative behavioral endophenotypes in order to more fully understand the genetic underpinnings and possible predisposing risk factors related to alcohol abuse.
Czachowski CL, DeLory MJ, Pope JD (2012) Behavioral and neurotransmitter specific roles for the ventral tegmental area in reinforcer-seeking and intake. Alcoholism: Clinical and Experimental Research 36(10):1659-68. PMCID: PMC3382024
Bertholomey ML, Verplaetse TL, Czachowski CL (2013) Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats. Behavioural Brain Research 238(1):252-8. PMCID: PMC3513579
Windisch KA, Kosobud AEK, Czachowski CL (2014) Intravenous alcohol self-administration in the P rat. Alcohol 48(5):419-25. PMCID: PMC4096581
Henderson-Redmond AN, Czachowski CL (in press) Effects of Systemic Opioid Receptor Ligands on Ethanol- and Sucrose Seeking and Drinking in Alcohol-Preferring (P) and Long Evans Rats Psychopharmacology DOI: 10.1007/s00213-014-3571-9
McCane AM, Czachowski CL, Lapish CC (in press) Tolcapone suppresses ethanol intake in alcohol preferring rats performing a novel cued access protocol. Alcoholism: Clinical and Experimental Research
Beckwith SW, Czachowski CL (in press) Increased delay discounting tracks with a high ethanol-seeking phenotype and subsequent ethanol-seeking but not consumption. Alcoholism: Clinical and Experimental Research