Andrew J. Saykin, Psy.D.
Raymond C. Beeler Professor of Radiology and Imaging Sciences
Professor of Medical and Molecular Genetics
Director, Indiana Alzheimer Disease Center
Director, Center for Neuroimaging
Psy.D., Hahnemann Medical College, Philadelphia (1982)
Brain Imaging and Genomic Approaches to Cognitive Disorders.
The combination of neuroimaging and genomic methods offers unprecedented scientific opportunities for systems biology research on brain structure and function. Our research program focuses on the structural, functional and molecular substrates of cognitive deficits in Alzheimer’s disease (AD) and memory, as well in cancer, traumatic brain injury, schizophrenia and other disorders. Within these areas a special focus includes the relationships among brain, gene and protein networks in diseases affecting memory and under normal conditions. The NIA-sponsored Indiana Alzheimer Disease Center (IADC) P30 has a strong focus on imaging, genetics and biomarkers. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) Genetics Core focuses on analysis of quantitative imaging and biomarker phenotypes. Our overall goal is to provide a better mechanistic understanding of early stage AD and other disorders of cognition to facilitate therapeutic development. Our laboratory includes graduate trainees in Medical Neuroscience and Medical and Molecular Genetics including MD/PhD students in the MSTP.
Selected Recent Publications
Neuroimaging Genomics – Pathways in Alzheimer’s Disease and Memory:
- Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA, for the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, for the AddNeuroMed Consortium, McDonald BC, Farlow MR, Ghetti B, for the Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ, for the Alzheimer's Disease Neuroimaging Initiative (ADNI). Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in Mild Cognitive Impairment. Molecular Psychiatry (2013, in press).
- Ramanan VK, Risacher SL, Nho K, Kim S, Swaminathan S, Shen L, Foroud TM, Hakonarson H, Huentelman MJ, Aisen PS, Petersen RC, Green RC, Jack CR, Koeppe RA, Jagust WJ, Weiner MW, Saykin AJ, for the ADNI. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Molecular Psychiatry; 2013, [online Feb 19], NIHMS: 435300.
- Swaminathan S, Shen L, Risacher SL, Yoder KK, West JD, Kim S, Nho K, Foroud T, Inlow M, Potkin SG, Huentelman MJ, Craig DW, Jagust WJ, Koeppe RA, Mathis CA, Jack CR Jr, Weiner MW, Saykin AJ; the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Brain Imaging Behav. 2012 Mar;6(1):1-15, [Epub 2011 Sep 8], PMCID: PMC3256261.
- Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR, Weiner MW, and the Alzheimer’s Disease Neuroimaging Initiative (2010). ADNI biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimer's & Dementia, 6:265-273, PMCID: PMC2868595.
- Sloan CD, Shen L, West JD, Wishart HA, Flashman LA, Rabin LA, Santulli RB, Guerin SJ, Rhodes CH, Tsongalis GJ, McAllister TW, Ahles TA, Lee SL, Moore JH, Saykin AJ (2010). Genetic Pathway-Based Hierarchical Clustering Analysis of Older Adults With Cognitive Complaints and Amnestic Mild Cognitive Impairment Using Clinical and Neuroimaging Phenotypes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2010 Jul;153B(5):1060-1069, PMCID: PMC3021757.
Neuroimaging and Biomarkers for Early Detection of Alzheimer’s Disease:
- Wang Y, Risacher SL, West JD, McDonald BC, MaGee TR, Farlow MR, Gao S, O'Neill DP, Saykin AJ. Altered DMN connectivity in older adults with cognitive complaints and amnestic MCI. J Alzheimers Dis. 2013 Mar 12. [Epub ahead of print], PMID: 23481685.
- Wang Y, West JD, Flashman LA, Wishart HA, Santulli RB, Rabin LA, Pare N, Arfanakis K, Saykin AJ. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim Biophys Acta: Molecular Basis of Disease, 1822(3):423-430, Mar 2012; PMCID: PMC3235544.
- Risacher SL, WuDunn D, Pepin SM, Magee TR, McDonald BC, Flashman LA, Wishart HA, Pixley HS, Rabin LA, Paré N, Englert JJ, Schwartz E, Curtain JR, West JD, O'Neill DP, Santulli RB, Newman RW, Saykin AJ. Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints. Neurobiol Aging. 2012 Oct 17 [Epub], NIHMSID: 401216 (PMC in progress).
- Risacher, S.L, Shen, L., West, J.D., Kim, S., McDonald, B.C., Beckett, L.A., Harvey, D.J., Jack, C.R., Weiner, M.W., Saykin, A.J., and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2010). Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort. Neurobiology of Aging, 31(8):1401-1418. Doi: 10.1016/j.neurobiolaging.2010.04.029, NIHMSID: 203913.
- Wang Y, Saykin AJ, Pfeuffer J, Lin C, Mosier KM, Shen L, Kim S, Hutchins GD (2011). Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T. NeuroImage, 54(2):1188-95, PMC2997151.
Traumatic Brain Injury - Neuroimaging and Genetic Factors:
- McAllister TW, McDonald BC, Flashman LA, Ferrell RB, Tosteson TD, Yanofsky NN, Grove MR, Saykin AJ. Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response. Int J Psychophysiol. [Epub 2011 Jul 19], PMID:21767584.
- McAllister TW, Flashman LA, McDonald BC, Ferrell RB, Tosteson TD, Yanofsky NN, Grove MR, Saykin AJ (2011). Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: altered working memory and BOLD response. J Neuropsychiatry Clin Neurosci; 23(3):277-86, PMID: 21948888.
- McAllister T, Tyler AL, Flashman LA, Rhodes CH, McDonald BC, Saykin AJ, Tosteson TD, Tsongalis GJ, Moore JH. Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury. J Neurotrauma 2012; 29(6):1111-18, PMID: 22188054.
Cancer and Cancer Treatment: Cognition, Imaging, Genetics, Interventions:
- Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-induced cognitive changes (2007). Nature Reviews Cancer, 7:192-201.
- Holohan KN, Lahiri DK, Schneider BP, Foroud T, Saykin AJ. Functional microRNAs in Alzheimer’s disease and cancer: Differential regulation of common mechanisms and pathways. Frontiers in Genetics, 2012;3:323 [Epub 2013 Jan 17], PMID: 23335942.
- McDonald BC, Conroy SK, Ahles TA, West JD, Saykin AJ (2010). Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study. Breast Cancer Research and Treatment. 123(3):819-828. Epub 2010 Aug 6, PMID: 20690040.
- McDonald BC, Saykin AJ (2011). Neurocognitive dimensions of breast cancer and its treatment. Neuropsychopharmacology, 36: 355-374.
- McDonald BC, Conroy SK, Ahles TA, West JD, Saykin AJ (2012). Alterations in brain activation during working memory processing associated with breast cancer and treatment: A prospective functional MRI study. Journal of Clinical Oncology. 2012 Jul 10;30(20):2500-8. Epub 2012 Jun 4, PMID: 22665542.
- McDonald BC, Conroy SK, Smith DJ, West JD, Saykin AJ (2012). Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study. Brain Behavior and Immunity. 2012 May 18. [Epub ahead of print], PMID: 22613170.
- Von Ah D, Carpenter JS, Saykin AJ, Monahan P, Wu J, Yu M, Rebok G, Ball K, Schneider B, Weaver M, Tallman E, Unverzagt F. Advanced cognitive training for breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat. 2012 Oct;135(3):799-809. Epub 2012 Aug 24, PMID: 22918524.