Yansheng Du, Ph.D.
Professor of Neurology
PhD, Wayne State University (1994)
Identification of Therapeutic Targets for Neurodegenerative Disorders.
The long term goal of my research is to elucidate molecular mechanisms which are responsible for the neuronal death and inflammation in neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, stroke, and Amyotrophic Lateral Sclerosis. The research will provide valuable information which may lead to the development of preventive and therapeutic approaches to these disorders. In particular, my interests include: 1) studying associations between specific genes and neurodegenerative disorders; 2) Using animal and cellular models for the mechanistic and therapeutic studies; 3) drug development.
The laboratory is a molecular cell biology laboratory. Most molecular and cell biology techniques performed in this laboratory include: PCR, genotyping, promoter study, cloning and expression, Southern, northern and western blotting, gel-shift assay, protein purification, immunocytochemistry, image analysis, ELISA, primary brain cell cultures, cell toxicity study, animal surgery, and analysis of transgenic mice. I have set up collaborations with clinical and basic research laboratories internationally.
Wei X, Du Z, Zhao L, Feng D, Wei G, He Y, Tan J, Lee WH, Hampel H, Dodel RC, Johnstone BH, March KL, Farlow MR, Du Y. The Conditioned Media of Adipose Stromal Cells Protect Against Hypoxia-Ischemia-Induced Brain Damage in Neonatal Rats. Stem Cells 2008 in press.
Lin S, Wei X, Bales KR, Paul ABC., Ma Z, Yan G, Paul SM, Du Y. Minocycline Blocks Bilirubin Neurotoxicity and Prevents Hyperbilirubinemia-Induced Cerebellar Hypoplasia in the Gunn Rat. Eur J Neurosci. 2005, 22:21-27.
Du Y, Wei X, Dodel RC, Sommer N, Hampel H, Gao F, Ma Z, Zhao L, Farlow MR. (2003). Human Anti-Ab Antibodies Block Ab Fibril Formation and Prevent Ab-induced Neurotoxicity. Brain 126(Pt 9):1935-9.
R Dodel, H Hampel, C Depboylu, S Lin, F Gao, S Schock, S Jäckel, X Wei, K Buerger, C Höft; B Hemmer, H Möller, M Farlow, WH Oertel, N Sommer, Du Y. (2002). Human Antibodies Against Amyloid -peptide, A Potential Treatment For Alzheimer Disease. Ann Neurol 52: 253-61.
Du Y, Ma, M, Lin, SZ, Gao, F., Dodel, RC, Bales, KR, Triarhou, LC, Chernet, E, Perry, K, Nelson, DLG, Luecke, S; Phebus, LA, Bymaster, FP, Paul, SM. (2001) Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson Disease. Proc. Natl. Acad. Sci. USA 2001 98: 14669-14674.