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Nicolas Berbari, Ph.D.

Assistant Professor, Biology
School of Science

Education/Training:

B.S., Indiana University, Biology (2002)
Ph.D., The Ohio State University, Biomedical Sciences (2008)
Postdoctoral, University of Alabama at Birmingham, Cell Biology (2014)

Cilia in the Central Nervous System.

Current work in the lab focuses on the roles of small hair-like cellular appendages called cilia. We are particularly interested in their roles in the brain. Interestingly, when cilia are disrupted in the feeding centers of the brain this results in obesity in both mice and patients with genetic disorders that affect cilia function. We are currently trying to determine how cilia can affect behaviors like appetite and satiety. We are utilizing conditional and congenital knockout mouse models, tissue culture, pharmacology and electrophysiology to address this question.

Search for Dr. Berbari on PubMed

Selected Publications:

Berbari N.F.#, Pasek R.C.#, Malarkey E.B., Yazdi S.M.Z. R., McNair A., Lewis W.R., Kesterson R.A., Nagy T., Yoder B.K. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.  Proc Natl Acad Sci U S A. 2013 May 7; 110 (19):7796-81. PMCID: PMC3651481

BerbariN.F. #, Malarkey E.B. #, Yazdi S.M.Z. R., McNairA.D., CroyleM.J., KraftT.W., YoderB.K. Hippocampal and Cortical Primary Cilia are Required for Aversive Memory. PLoS One. 2014 Sep 3;9(9):e106576. doi: 10.1371/journal.pone.0106576. eCollection 2014. PMCID: PMC4153651

Berbari N.F., O’Connor A.K., Haycraft C.J., Yoder B.K. The Cilium as a Complex Signaling Center. Curr Biol. 2009 Jul 14; 1913):R526-35.

Berbari N.F., Pasek R.C., Yoder B.K. Neuronal Cilia in Obesity. Chapter in “Cilia in Neuroscience” Springer Press. 2013.

Stark Neurosciences Research Institute | Neuroscience Research Building | 320 West 15th Street | Indianapolis, IN 46202 | Phone: (317) 278-5848 | FAX: (317) 231-0203