William J. McBride Jr., Ph.D.
Professor of Neurobiology and Biochemistry in the Department of Psychiatry
Ph.D. Biochemistry State University of New York at Buffalo (1968)
Brain mechanisms involved in alcohol addiction.
Research programs are involved in characterizing the selective bred alcohol-preferring (P) and high-alcohol-drinking (HAD) rats as animal models of alcoholism. Alcohol research activities include determining the neurobiological basis of high alcohol drinking behavior, long-range consequences of adolescent alcohol drinking, mechanisms underlying alcohol craving and relapse, mechanisms underlying the reinforcing effects of alcohol, and animal models of binge drinking.
One project utilizes microdialysis and [14C]-2-deoxyglucose brain imaging to examine brain mechanisms involved in alcohol drinking in selectively bred alcohol preferring rats. A second project utilizes behavioral (e.g., operant, acoustic startle response, etc) and neurobiological (e.g., microdialysis and [14C]-2-deoxyglucose) to examine the long-term consequences of adolescent alcohol drinking. A third project uses intracranial self-administration methodology to determine brain sites and neurotransmitter system mediating the reinforcing effects of ethanol. A fourth project uses microarray and proteomics techniques to examine the consequences of alcohol drinking by high-alcohol-drinking and alcohol-preferring lines of rats. Two other projects utilizes a variety of techniques (operant, intracranial self-administration, pharmacological, microdialysis, brain imaging, etc) to examine neurobiological mechanisms underlying alcohol craving and relapse.
Starkey JA, Mechref Y, Muzikar J, McBride WJ, Novotny MV. Determination of Salsolinol and Related Catecholamines through On-Line Preconcentration and Liquid Chromatography/Atmospheric Pressure Photoionization Mass Spectrometry.
Anal Chem. 2006 May 15;78(10):3342-7.
Rodd ZA, McKinzie DL, Bell RL, McQueen VK, Murphy JM, Schoepp DD, McBride WJThe metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.
Behav Brain Res. 2006 May 5; [Epub ahead of print]
Sable HJ, Bell RL, Rodd ZA, McBride WJ. Effects of naltrexone on the acquisition of alcohol intake in male and female periadolescent and adult alcohol-preferring (P) rats.
Int J Adolesc Med Health. 2006 Jan-Mar;18(1):139-49.
Rossi EA, Goldenberg DM, Cardillo TM, McBride WJ, Sharkey RM, Chang CH. Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6841-6.
Klouckova I, Hrncirova P, Mechref Y, Arnold RJ, Li TK, McBride WJ, Novotny MV.Changes in liver protein abundance in inbred alcohol-preferring rats due to chronic alcohol exposure, as measured through a proteomics approach.Proteomics. 2006 May;6(10):3060-74.