William A. Truitt, Ph.D.
Associate Professor of Anatomy & Cell Biology
Ball State University, BS (1992)
Ball State University, MA (1998)
Texas Woman's University, PhD (2000)
University of Cincinnati School of Medicine, Postdoctoral Fellowship (2000-2003)
Neurobiology of anxiety disorders.
My overall research objective is to understand the neural circuitry that regulates anxiety and how manipulations of this circuit leads to pathological anxiety and panic. It is my hope that findings from these types of experiments will lead to novel treatments for anxiety and panic disorders. My lab utilizes behavioral pharmacology coupled with neuranatomy and molecular biology to elucidate the functional circuits of anxiety behaviors. Of particular interest to me is how the interneurons of the basolateral amygdala interact with the projections neurons of this nucleus to induce or suppress anxiety-like behaviors. In doing so I hope to understand the mechanism by which subtle manipulations to this system can produce chronic anxiety-like symptoms. This systems approach to research leads to highly detailed understanding of these circuit as well as produce insights to the mechanisms of the behavioral outcomes.
S. Maswood, W. Truitt, M. Hotema, M. Caldarola-Pastuszka and L. Uphouse. Estrous cycle modulation of extracellular serotonin in mediobasal hypothalamus: role of the serotonin transporter and terminal autoreceptors. Brain Res. 1999 Jun 12;831(1-2): 146-54 (PMID: 10411994)
W. A. Truitt and Lique M. Coolen, Identification of a Potential Ejaculation Generator in the Spinal Cord Science Aug 30 2002: 1566-1569. (PMID: 12202834)
W.A. Truitt, M.T. Shipley, J.G. Veening, and L.M. Coolen, Activation of a Subset of Lumbar Spinothalamic Neurons following Copulatory Behavior in Male but not Female Rats. J. Neurosci. Jan 1;23(1):325-31 (PMID: 12514231)
W.A. Truitt and L. Uphouse. Progesterone attenuates the effect of the 5-HT1A receptor agonist, 8-OH-DPAT, and of mild restraint on lordosis behavior. Brain Res. 2003 Jun 6;974(1-2):202-11 (PMID: 12742638)
L. Uphouse, S. White, L. Harrison, C, Hiegel, D. Majumdar, J. Guptarak and W. A. Truitt. Restraint accentuates the effects of 5-HT(2) receptor antagonists and a 5-HT(1A) receptor agonist on lordosis behavior. Pharmacol Biochem Behav. 2003 Aug;76(1):63-73 (PMID: 13679218)
L.M. Coolen, J. Allard, W.A. Truitt and K.E. McKenna. Central regulation of ejaculation. Physiology and Behavior. 2004 Nov; 15;83(2): 203-15 (PMID: 15488540)
J. Allard, W.A. Truitt, K.E. McKenna and L.M. Coolen. Spinal cord control of ejaculation. World J. Urology 2005 Jun; 23(2) 119-26 (PMID: 15947961)
A. Shekhar, W. Truitt, D. Rainnie, and T. Sajdyk, Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety. Stress. 2005 Dec;8(4):209-19 (PMID: 16423710)
W.A. Truitt, T.J. Sajdyk, A.D. Dietrich, B. Oberlin, C.J. McDougle and A. Shekhar, From anxiety to autism: spectrum of abnormal social behaviors modeled by progressive disruption of inhibitory neuronal function in the basolateral amygdala in Wistar rats Psychopharmacology 2007 Mar;191(1):107-18 (PMID: 17277936)
P.L. Johnson, W.A. Truitt, S.D. Fitz, C.A. Lowry and A. Shekhar, (2008). Neural pathways underlying lactate induced panic. Neuropsychopharm. 2008 Aug;33(9):2093-107 (PMID: 18059441)
P.L. Johnson, C.A. Lowry, W.A. Truitt and A. Shekhar Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates lactate-induced responses in a subset of serotonergic neurons in the dorsal raphe nucleus J. Psychopharmacology 2008 Aug;22(6):642-52 (PMID: 18308791)
W.A. Truitt, P.L. Johnson, A.D. Dietrich, S.D. Fitz, and A. Shekhar, Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala. Neuroscience 2009 May 5;160(2):284-94 (PMC2682359)
I. Obara, R.L. Bell, S.P. Goulding, C.M. Reyes, L.A. Larson, A.W. Ary, W.A. Truitt, K.K. Szumlinski. Subregional Selectivity in the Effects of Alcohol Withdrawal upon Homer/Glutamate Receptor Expression in the Accumbens and Amygdala of P Rats. Alcoholism: Clinical and Experimental Research 2009 Nov;33(11):1924-34 (PMC2873844)
R.A. Chambers, A.M. Sentir, S.K. Conroy, W.A. Truitt, A. Shekhar. Cortical-striatal integration of cocaine history and hypofrontality underlies augmented long-term behavioral sensitization in the neonatal ventral hippocampal lesion rat model of schizophrenia Biological Psychiatry 2010 Apr 15;67(8):788-92 (PMC2849854)
P.L. Johnson, W.A. Truitt, S.D. Fitz, P.E. Minick, A. Dietrich, S. Sanghani, L. Traskman-Bendz, A.W. Goddard, L. Brundin, A. Shekhar. A key role for orexin in panic anxiety. Nat Med 2010 Jan;16(1):111-5 (PMC2832844)
J.L. Lukke, D.R. Staub, A. Dietrich, W.A. Truitt, A. Neufeld-Cohen, A. Chen, P.L. Johnson, A.Shekhar, and C.A. Lowry. Topographical distribution of corticotropin-releasing factor type 2 (CRF2) receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylase. Neuroscience 2011 Jun 2;183:47-63 (PMC3092641)