Marian L. Logrip, Ph.D.
Assistant Professor, Psychology
Ph.D., Neuroscience, University of California, San Francisco (2007)
The central focus of my laboratory is the elucidation of sexually dimorphic molecular, circuit-level and behavioral adaptations to stressful experiences, using a rodent model to investigate the sources of stress-related psychiatric disorders and their impact on alcohol use disorders. I seek to identify the underlying causes of females’ greater propensity to develop mental illness following traumatic experiences in order to identify novel treatments for these intractable disorders. Currently, my research synthesizes molecular, electrophysiological and behavioral techniques to elucidate mechanisms supporting comorbid alcohol use and stress-related psychiatric disorders, with a particular focus on amygdala-centered signaling. By combining investigation of changes in mRNA expression, protein expression, and neuronal activity with stress- and/or alcohol-related behavioral assessments, we can obtain a broad picture of the dysfunctionality of stress-induced neuroadaptations. The long range implications for this research are the possible identification of novel treatment targets for affective, anxiety and alcohol use disorders that may be differentially efficacious in males and females.
- McGough NNH, He D-Y, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. (2004). RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. The Journal of Neuroscience 24:10542-10552.
- Logrip ML, Janak PH, Ron D. (2008). Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. The FASEB Journal 22:2393-2404.
- Logrip ML, Janak PH, Ron D. (2009). Escalating ethanol intake is associated with altered corticostriatal BDNF expression. The Journal of Neurochemistry 109:1459-1468. PMC2847400.
- Jeanblanc J, Logrip ML, Janak PH, Ron D. (2013). BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. European Journal of Neuroscience, 37:607-612. PMC3577946.Logrip ML, Zorrilla EP. (2012). Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A. Addiction Biology, 17:920-933. PMC3444642.
- Logrip ML, Zorrilla EP. (2014). Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Frontiers in Integrative Neuroscience, 8:30. PMC3986522.
- Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. (2014). Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology, 39:1722-1731. PMC4023146.
- Logrip ML. (2015). Phosphodiesterase regulation of alcohol drinking in rodents. Alcohol S0741-8329: 20270-4. PMC4663182.
- Logrip ML, Rivier C, Lau C, Im S, Vaughan J, Lee S. (2013). Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary-adrenal axis responsiveness in a sex-specific manner. Neuroscience, 3:174-186. PMC3595399.