Leonid L. Rubchinsky, Ph.D.

Associate Professor, Mathematical Sciences

Ph.D. Physics, Institute of Applied Physics, Russian Academy of Science (2000)
Postdoctoral, University of California, Davis (2001-2004)
M.S. University of California, SanDiego (1997)

Oscillations and Synchronization in Neural Circuits, Computational Neuroscience of Parkinson’s disease and addiction.

I am a computational neuroscientist and mathematical biologist. I use methods and ideas of dynamical systems theory in application to neuroscience. For the past decade or so years my research interest was focused on the mechanisms and functions of synchronous dynamics in different neural systems. I closely collaborate with clinical and experimental neuroscientists in a quest to detect, describe, model, and eventually control neural oscillations and synchrony. I use data-analysis, computational modeling and analytical techniques to study mechanisms, functions and dysfunctions of neural synchronization mostly in application to neurophysiology of Parkinson’s disease and disorders of addiction.

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Recent Publications:

S. Ahn, L. L. Rubchinsky, C.C. Lapish (2014) Dynamical reorganization of synchronous activity patterns in prefrontal cortex - hippocampus networks during behavioral sensitization. Cerebral Cortex. Accepted, bht110 first published online doi: 10.1093/cercor/bht110.

S. E. Zauber, S. Ahn, R.M. Worth, L.L. Rubchinsky (2014) Oscillatory neural activity of anteromedial Globus Pallidus internus in Tourette syndrome. Clin Neurophysiol 125:1923.

L.L. Rubchinsky, S. Ahn, C. Park (2014) Dynamics of synchronization-desynchronization transitions in intermittent synchronization. Frontiers in Computational Physics 2:38.

S. Ahn, J. Solfest, L.L. Rubchinsky (2014) Fine temporal structure of cardiorespiratory synchronization. American Journal of Physiology - Heart and Circulatory Physiology 306: H755-H763.

Y. Guo, C. Park, R.M. Worth, L.L. Rubchinsky (2013) Basal ganglia modulation of thalamocortical relay in Parkinson’s disease and dystonia. Frontiers in Computational Neuroscience 7: 124.

A. Dovzhenok, C. Park, R.M. Worth, L.L. Rubchinsky (2013) Failure of Delayed Feedback Deep Brain Stimulation for Intermittent Pathological Synchronization in Parkinson's Disease. PLoS ONE 8(3): e58264.

S. Ahn, D.N. Linsenbardt, C.C. Lapish, L.L. Rubchinsky (2013) Repeated injections of D-Amphetamine evoke rapid and dynamic changes in phase synchrony between the prefrontal cortex and hippocampus. Frontiers in Behavioral Neuroscience 7: 92.

S. Ahn, L.L. Rubchinsky (2013) Short desynchronization episodes prevail in the synchronous dynamics of human brain rhythms. Chaos 23: 013138.

C. Park, L.L. Rubchinsky (2012) Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia. PLoS ONE 7(12):e51530.

L.L. Rubchinsky, C. Park, R.M. Worth (2012) Intermittent neural synchronization in Parkinson's disease. Nonlinear Dynamics 68: 329-346.

A. Dovzhenok, L.L. Rubchinsky (2012) On the origin of tremor in Parkinson's disease. PLoS ONE 7(7):  e41598.

C. Park, L.L. Rubchinsky (2011) Intermittent synchronization in a network of bursting neurons. Chaos 21: 033125.

S. Ahn, C. Park, L.L. Rubchinsky (2011) Detecting the temporal structure of intermittent phase locking. Phys. Rev. E 84: 016201.

C. Park, R.M. Worth, L.L. Rubchinsky (2011) Neural Activity in Parkinsonian Brain: the Boundary Between Synchronized and Nonsynchronized Dynamics. Phys. Rev. E 83: 042901.                                                                                                                            

S. Ahn, L.L. Rubchinsky, C.C. Lapish (2014)  Dynamical reorganization of synchronous activity patterns in prefrontal cortex - hippocampus networks during behavioral sensitization. Cerebral Cortex 24:2553-2561.

S Ratnadurai-Giridharan, SE Zauber, RM Worth, T Witt, S Ahn, LL Rubchinsky (2016) Temporal patterning of neural synchrony in the basal ganglia in Parkinson's disease. Clinical Neurophysiology 127:1743-1745.

S Ahn, SE Zauber, RM Worth, T Witt, LL Rubchinsky (2015) Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease. European Journal of Neuroscience 42:2164-2171.

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