Eric A. Engleman, Ph.D.
Associate Professor of Psychiatry
Ph.D., Indiana University (1992)
Postdoctoral, Eli Lilly Research Labs (1992-96)
Neurobiology of Addiction.
I study the neurobiology of addiction using animal models including alcohol-preferring rodent lines, and more recently, the nematode Caenorhabditis elegans (C. elegans). I use neurochemical and pharmacological techniques to study (1) the differences in neurotransmission in specific central nervous system sites and circuits that are associated with genetic models of alcoholism and (2) the neuroadaptations in these circuits that result from drug intake and subsequent deprivation which may be associated with the initiation or maintenance of drug taking, relapse, and/or the transition from drug use to drug dependence. I also have a particular interest in adolescence and the consequences of ethanol and nicotine co-abuse in adolescence on the function of the mesocorticolimbic brain reward system and the long-range effects on drug abuse in adulthood.
I am also working to develop new models of addiction using C. elegans. We have found that C. elegans show attraction and self-exposure to various drugs of abuse. Like humans, we have found that when a neutral cue in the environment is paired with a drug, and thus predicts the presence of the drug, C. elegans begin to seek out that cue – even in the absence of the drug. We are also studying how exposure to drugs during development affects responses to drugs in adulthood. We plan to take advantage of the simple and well described neurobiology of C. elegans and leverage the genetic and molecular tools available to study this organism to better understand the basic mechanisms that underlie addiction and identify new effective treatments.
The 5-HT7 receptor as a potential target for treating drug and alcohol abuse. Hauser SR, Hedlund PB, Roberts AJ, Sari Y, Bell RL, Engleman EA. Front Neurosci. 8:448. 2015.
Nicotine effects in adolescence and adulthood on cognition and α?β?-nicotinic receptors in the neonatal ventral hippocampal lesion rat model of schizophrenia. Berg SA, Sentir AM, Bell RL, Engleman EA, Chambers RA. Psychopharmacology (Berl). 232:1681-92. 2015.
Time-course of extracellular nicotine and cotinine levels in rat brain following administration of nicotine: effects of route and ethanol coadministration. Katner SN, Toalston JE, Smoker MP, Rodd ZA, McBride WJ, Engleman EA. Psychopharmacology (Berl). 232:551-60. 2015.
The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats. Toalston JE, Deehan GA Jr, Hauser SR, Engleman EA, Bell RL, Murphy JM, McBride WJ, Rodd ZA. Alcohol. 49:513-8. 2015.
Nicotinic receptor modulation to treat alcohol and drug dependence. Rahman S, Engleman EA, Bell RL. Front Neurosci. 8:426. 2015.
Caenorhabditis elegans as a model to study the molecular and genetic mechanisms of drug addiction. Engleman EA, Katner SN, Neal-Beliveau BS. Prog Mol Biol Trans Sci. 2016 in press.