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Christopher C. Lapish, Ph.D.

Assistant Professor of Psychology

Education/Training:
Research Associate Professor, Brain Research Centre, University of British Columbia, (2008-2010)
Postdoctoral, Brain Research Centre, University of British Columbia, (2006-2008)

PhD, Medical University of South Carolina, Charleston, SC (2006)
Bs, Clemson University, Clemson, SC (1999)


Current Research:
Multiple neuropsychiatric disorders are characterized by deficits in cognition. The primary focus of my research is to understand the neurophsyiological basis of cognition and explore potential procognitive treatment vectors for disorders such as schizophrenia and addiction. My lab performs electrophysiological recordings in areas of the brain known to perform computations necessary for various forms of cognition such as working memory and attention. I am especially interested in how the neurotransmitter dopamine influences interactions amongst large neural populations. Understanding how dopamine shapes the population dynamic is crucial to our understanding of cognition and how dopamine-mediated signaling may be altered in neuropsychiatric illness.


Selected Publications:

Linsenbardt DN, Lapish CC. Neural Firing in the Prefrontal Cortex During Alcohol Intake in Alcohol-Preferring "P" Versus Wistar Rats. Alcohol Clin Exp Res. 2015 Aug 6. doi: 10.1111/acer.12804. [Epub ahead of print] PubMed PMID: 26250465.

Lapish CC, Balaguer-Ballester E, Seamans JK, Phillips AG, Durstewitz D. Amphetamine Exerts Dose-Dependent Changes in Prefrontal Cortex Attractor Dynamics during Working Memory. J Neurosci. 2015 Jul 15;35(28):10172-87. doi: 10.1523/JNEUROSCI.2421-14.2015. PubMed PMID: 26180194; PubMed Central PMCID: PMC4502258.

Janetsian SS, Linsenbardt DN, Lapish CC. Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization. Psychopharmacology (Berl). 2015 Jun;232(12):2083-95. doi: 10.1007/s00213-014-3840-7. Epub 2015 Jan 10. PubMed PMID: 25572530; PubMed Central PMCID: PMC4433565.

Lapish CC, Ahn KC, Chambers RA, Ashby DM, Ahn S, Phillips AG. Selective effects of D- and L-govadine in preclinical tests of positive, negative, and cognitive symptoms of schizophrenia. Neuropsychopharmacology. 2014 Jun;39(7):1754-62. doi: 10.1038/npp.2014.23. Epub 2014 Jan 30. PubMed PMID: 24476944; PubMed Central PMCID: PMC4023149.

Ahn S, Rubchinsky LL, Lapish CC. Dynamical reorganization of synchronous activity patterns in prefrontal cortex-hippocampus networks during behavioral sensitization. Cereb Cortex. 2014 Oct;24(10):2553-61. doi: 10.1093/cercor/bht110. Epub 2013 May 3. PubMed PMID: 23645713.

Lapish CC, Belardetti F, Ashby DM, Ahn S, Butts KA, So K, Macrae CM, Hynd JJ, Miller JJ, Phillips AG. A preclinical assessment of d.l-govadine as a potential antipsychotic and cognitive enhancer. Int J Neuropsychopharmacol. 2012 Nov;15(10):1441-55. doi: 10.1017/S146114571100157X. Epub 2011 Nov 10. PubMed PMID: 22071247.

Balaguer-Ballester E, Lapish CC, Seamans JK, Durstewitz D. Attracting dynamics of frontal cortex ensembles during memory-guided decision-making. PLoS Comput Biol. 2011 May;7(5):e1002057. doi: 10.1371/journal.pcbi.1002057. Epub 2011 May 19. PubMed PMID: 21625577; PubMed Central PMCID: PMC3098221.

Seamans JK, Lapish CC, Durstewitz D. Comparing the prefrontal cortex of rats and primates: insights from electrophysiology. Neurotox Res. 2008 Oct;14(2-3):249-62. doi: 10.1007/BF03033814. Review. PubMed PMID: 19073430.

Lapish CC, Durstewitz D, Chandler LJ, Seamans JK. Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortex. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11963-8. doi: 10.1073/pnas.0804045105. Epub 2008 Aug 15. PubMed PMID: 18708525; PubMed Central PMCID: PMC2516968.

Lapish CC, Kroener S, Durstewitz D, Lavin A, Seamans JK. The ability of the mesocortical dopamine system to operate in distinct temporal modes. Psychopharmacology (Berl). 2007 Apr;191(3):609-25. Epub 2006 Nov 4. Review. PubMed PMID: 17086392.

Lapish CC, Seamans JK, Chandler LJ. Glutamate-dopamine cotransmission and reward processing in addiction. Alcohol Clin Exp Res. 2006 Sep;30(9):1451-65. PubMed PMID: 16930207.

Stark Neurosciences Research Institute | Neuroscience Research Building | 320 West 15th Street | Indianapolis, IN 46202 | Phone: (317) 278-5848 | FAX: (317) 231-0203