Search

Brenna C. McDonald, Psy.D., M.B.A., ABPP-CN

Associate Professor of Radiology and Imaging Sciences and Neurology
Associate Director, Indiana University Center for Neuroimaging
Director, Pediatric Neuropsychology

Education/Training:
B.A., Williams College (1994)
M.A., Widener University (1998)

Psy.D & M.B.A, Widener University (2000)

Brain Imaging and Cognitive Dysfunction in Pediatric Neuropsychiatric Disorders.

Dr. McDonald's primary research interests are in structural and functional neuroimaging of pediatric populations, particularly those with neurological or neurodevelopmental disorders (e.g., traumatic brain injury, cancer, epilepsy), as well as children at risk for neuropsychiatric disorders. Funded research projects include investigation of alterations in brain blood flow after adolescent sports-related concussion, effects of pediatric leukemia chemotherapy on brain structure and function, memory and language processing in children with temporal lobe epilepsy, and development of a child and adolescent normative database for clinical fMRI studies. Dr. McDonald is also involved in ongoing research in adult populations. She is a co-investigator in the Indiana Alzheimer Disease Center, as well as on projects examining the cognitive effects of cancer chemotherapy (PI: Andrew Saykin, PsyD), and multiple clinical trials and observational studies of adult traumatic brain injury (TBI) (PI: Thomas McAllister, MD).

Search for Dr. McDonald on PubMed

Selected Publications:

Cognitive Effects of Cancer and Treatment:

Ferguson, R. J., McDonald, B. C., Saykin, A. J., & Ahles, T. A. (2007). Brain structure and function differences in monozygotic twins: Possible effects of breast cancer chemotherapy. Journal of Clinical Oncology, 25, 3866-3870.  

McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J. (2010). Gray matter reduction associated with systemic chemotherapy for breast cancer: A prospective MRI study. Breast Cancer Research and Treatment, 123, 819-828.  

McDonald, B. C. & Saykin, A. J. (2011). Neurocognitive dimensions of breast cancer and its treatment. Neuropsychopharmacology, 36, 355-374.  

Ferguson, R. J., McDonald, B. C., Rocque, M., Furstenberg, C. T., Horrigan, S., Ahles, T. A., & Saykin, A. J. (2012). Development of CBT for chemotherapy-related cognitive change: Results of a waitlist control trial. Psycho-Oncology, 21, 176-186. 

McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J. (2012). Alterations in brain activation during working memory processing associated with breast cancer and treatment: A prospective functional MRI study. Journal of Clinical Oncology, 30, 2500-2508.  

Conroy, S. K., McDonald, B. C., Smith, D. J., Moser, L. R., West, J. D., Kamendulis, L. M., Klaunig, J. E., Champion, V. L., Unverzagt, F. W., & Saykin, A. J. (2013). Alterations in brain structure and function in breast cancer survivors: Effect of post-chemotherapy interval and relation to oxidative DNA damage. Breast Cancer Research and Treatment, 137, 493-502.

McDonald, B. C., Conroy, S. K., Smith, D. J., West, J. D., & Saykin, A. J. (2013). Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study. Brain, Behavior, and Immunity, 30, S117-S125.

McDonald, B. C. & Saykin, A. J. (2013). Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations. Brain Imaging and Behavior, 7, 374-387.

Conroy, S. K., McDonald, B. C., Ahles, T. A., West, J. D., & Saykin, A. J. (2013) Chemotherapy-induced amenorrhea: A prospective study of brain activation changes and cognitive correlates. Brain Imaging and Behavior, 7, 491-500.  

Nudelman, K. N. H., McDonald, B. C., Wang, Y., Smith, D. J., West, J. D., O’Neill, D. P., Zanville, N. R., Champion, V. L., Schnieder, B. P., & Saykin, A. J. (2016). Cerebral perfusion and gray matter changes associated with chemotherapy-induced peripheral neuropathy (CIPN). Journal of Clinical Oncology, 34, 677-683.

Traumatic Brain Injury (TBI): 

McDonald, B. C., Flashman, L. A., & Saykin, A. J. (2002). Executive dysfunction following traumatic brain injury: Neural substrates and treatment strategies. NeuroRehabilitation, 17, 333-344.  

McAllister, T. W., Rhodes, C. H., Flashman, L. A., McDonald, B. C., Belloni, D., & Saykin, A. J. (2005). Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. American Journal of Psychiatry, 162, 1749-1751.  

Duhaime, A. C., Saykin, A. J., McDonald, B. C., Dodge, C. P., Eskey, C. J., Darcey, T. M., Grate, L. L., & Tomashosky, P. (2006). Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. Journal of Neurosurgery, 104, 259-264.

McAllister, T. W., Flashman, L. A., McDonald, B. C., & Saykin, A. J. (2006). Mechanisms of working memory dysfunction after mild and moderate TBI: Evidence from functional MRI and neurogenetics. Journal of Neurotrauma, 23, 1450-1467.  

McAllister, T. W., Flashman, L. A., Rhodes, C. H., Tyler, A. L., Moore, J. H., Saykin, A. J., McDonald, B. C., Tosteson, T. D., & Tsongalis, G. J. (2008). Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: A replication and extension study. Brain Injury, 22, 705-714. 

McAllister, T. W., Tyler, A. L., Flashman, L. A., Rhodes, C. H., McDonald, B. C., Saykin, A. J., Tosteson, T. D., Tsongalis, G. J., & Moore, J. H. (2012). Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury. Journal of Neurotrauma, 29, 1111-1118.  

McDonald, B. C., Saykin, A. J., & McAllister, T. W. (2012). Functional MRI of mild traumatic brain injury (mTBI): Progress and perspectives from the first decade of studies. Brain Imaging and Behavior, 6, 193-207.

Neumann, D. Keiski, M. A., McDonald, B. C., & Wang, Y. (2014). Neuroimaging and facial affect processing: Implications for traumatic brain injury. Brain Imaging and Behavior, 8, 460-473.

Wang, Y., West, J. D., Bailey, J. N., Westfall, D. R., Xiao, H., Arnold, T. W., Kersey, P. A., Saykin, A. J., & McDonald, B. C. (2015). Decreased cerebral blood flow in chronic pediatric mild TBI: An MRI perfusion study. Developmental Neuropsychology, 40, 40-44.

Westfall, D. R., West, J. D., Bailey, J. N., Arnold, T. W., Kersey, P. A., Saykin, A. J., & McDonald, B. C. (2015). Increased brain activation during working memory processing after pediatric mild traumatic brain injury (mTBI). Journal of Pediatric Rehabilitation Medicine, 8, 297-308.

Neumann, D., McDonald, B. C., West, J. D., Keiski, M. A., & Wang, Y. (2015, online ahead of print). Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury. Brain Imaging and Behavior.

Pharmacological Effects on Cognitive Function:

Dumas, J. A., Saykin, A. J., McDonald, B. C., McAllister, T. W., Hynes, M. L., & Newhouse, P. A. (2008). Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women. American Journal of Geriatric Psychiatry, 16, 272-282.   

Dumas, J. A., McDonald, B. C., Saykin, A. J., McAllister, T. W., Hynes, M. L., West, J. D., & Newhouse, P. A. (2010). Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: A pilot study. Menopause: The Journal of the North American Menopause Society, 17, 852-859.  

McAllister, T. W., Flashman, L. A., McDonald, B. C., Ferrell, R. B., Tosteson, T. D., Yanofsky, N. N., & Saykin, A. J. (2011). Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: Altered working memory and BOLD response. The Journal of Neuropsychiatry and Clinical Neurosciences, 23, 277-286.  

McAllister, T. W., McDonald, B. C., Flashman, L. A., Ferrell, R. B., Tosteson, T. D., Yanofsky, N. N., Grove, M. R., & Saykin, A. J. (2011). Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response. International Journal of Psychophysiology, 82, 107-114.  

Risacher, S. L., Wang, Y., Wishart, H. A., Rabin, L. A., Flashman, L. A., McDonald, B. C., West, J. D., Santulli, R. B., & Saykin, A. J. (2013). Cholinergic enhancement of brain activation in mild cognitive impairment during episodic memory encoding. Frontiers in Psychiatry, 4:105.

Risacher, S. L., McDonald, B. C., Tallman, E. M., West, J. D., Farlow, M. R., Unverzagt, F. W., Gao, S., Boustani, M., Crane, P. K., Petersen, R. C., Jack, Jr., C. R., Jagust, W. J., Aisen, P. S., Weiner, M. W., & Saykin, A. J., for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2016, online ahead of print). Relationship between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurology.

Stark Neurosciences Research Institute | Neuroscience Research Building | 320 West 15th Street | Indianapolis, IN 46202 | Phone: (317) 278-5848 | FAX: (317) 231-0203