Brenna C. McDonald, Psy.D., M.B.A.

Associate Professor of Radiology and Neurology

Psy.D & M.B.A, Widener University (2000)

Brain Imaging and Cognitive Dysfunction in Pediatric Neuropsychiatric Disorders.

Dr. McDonald's primary research interests are in structural and functional neuroimaging of pediatric populations, particularly those with neurological or neurodevelopmental disorders (traumatic brain injury, epilepsy, cancer, autism spectrum disorders), as well as children at risk for neuropsychiatric disorders. Current funded research projects include investigation of memory and language processing in temporal lobe epilepsy in young children and development of a child and adolescent normative database for clinical fMRI studies. Dr. McDonald is also involved in ongoing research in adult populations, including work at IU examining the cognitive effects of cancer chemotherapy (PI: Andrew Saykin, PsyD), and collaboration with colleagues at Dartmouth Medical School studying adult TBI (PI: Thomas McAllister, MD).

Recent Publications:

Zimmerberg, B. & McDonald, B. C. (1996). Prenatal alcohol exposure influences the effects of neuroactive steroids on separation-induced ultrasonic vocalizations in rat pups. Pharmacology, Biochemistry and Behavior, 55, 541-547.

McDonald, B. C. (2002). Recent developments in the application of the nonverbal learning disabilities model. Current Psychiatry Reports, 4, 323-330.

McDonald, B. C., Flashman, L. A., & Saykin, A. J. (2002). Executive dysfunction following traumatic brain injury: Neural substrates and treatment strategies. NeuroRehabilitation, 17, 333-344.

Wishart, H. A., Roberts, D. W., Roth, R. M., McDonald, B. C., Coffey, D. J., Mamourian, A. C., Hartley, C., Flashman, L. A., Fadul, C. E., & Saykin, A. J. (2003). Chronic deep brain stimulation for the treatment of tremor in multiple sclerosis: Review and case reports. Journal of Neurology, Neurosurgery & Psychiatry, 74, 1392-1397.

Saykin, A. J., Ahles, T. A., & McDonald, B. C. (2003). Mechanisms of chemotherapy-induced cognitive disorders: Neuropsychological, pathophysiological and neuroimaging perspectives. Seminars in Clinical Neuropsychiatry, 8, 201-216.

Wishart, H. A., Saykin, A. J., McDonald, B. C., Mamourian, A. C.,  Flashman, L. A., Schuschu, K. R., Ryan, K. A., Fadul, C. E., & Kasper, L. H. (2004). Brain activation patterns associated with working memory in relapsing-remitting MS. Neurology, 62, 234-238.

McAllister, T. W., Ahles, T. A., Saykin, A. J., Ferguson, R. J., McDonald, B. C., Lewis, L. D., Flashman, L. A., & Rhodes, C. H. (2004). Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments. Current Psychiatry Reports, 6, 364-371.

Randolph, J. J., Wishart, H. A., Saykin, A. J., McDonald, B. C., Schuschu, K. R., MacDonald, J. W., Mamourian, A. C., Fadul, C. E., Ryan, K. A., & Kasper, L. H. (2005). FLAIR lesion volume in multiple sclerosis: Relation to processing speed and verbal memory. Journal of the International Neuropsychological Society, 11, 205-209.

McAllister, T. W., Rhodes, C. H., Flashman, L. A., McDonald, B. C., Belloni, D., & Saykin, A. J. (2005). Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. American Journal of Psychiatry, 162, 1749-1751.

Duhaime, A. C., Saykin, A. J., McDonald, B. C., Dodge, C. P., Eskey, C. J., Darcey, T. M., Grate, L. L., & Tomashosky, P. (2006). Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. Journal of Neurosurgery, 104, 259-264.

McAllister, T. W., Flashman, L. A., McDonald, B. C., & Saykin, A. J. (2006). Mechanisms of working memory dysfunction after mild and moderate TBI: Evidence from functional MRI and neurogenetics. Journal of Neurotrauma, 23, 1450-1467.

Wishart, H. A., Saykin, A. J., McAllister, T. W., Rabin, L. A., McDonald, B. C., Flashman, L. A., Roth, R. M., Mamourian, A. C., Tsongalis, G. J., Rhodes, C. H. (2006). Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele. Neurology, 67, 1221-1224.

Ferguson, R. J., Ahles, T. A., Saykin, A. J.,  McDonald, B. C., Furstenberg, C. T., Cole, B. F., Mott, L. A. (2007). Cognitive-behavioral management of chemotherapy-related cognitive change. Psycho-Oncology, 16, 772-777.

Ferguson, R. J., McDonald, B. C., Saykin, A. J., Ahles, T. A. (2007). Brain structure and function differences in monozygotic twins: Possible effects of breast cancer chemotherapy. Journal of Clinical Oncology, 25, 3866-3870.

Dinnerstein, E., McDonald, B. C., Cleavinger, H. B., Thadani, V. M., Jobst, B.C. (2008). Mesial temporal sclerosis after status epilepticus due to milk alkali syndrome. Seizure, 17, 292-295.

Dumas, J. A., Saykin, A. J., McDonald, B. C., McAllister, T. W., Hynes, M. L., Newhouse, P. A. (2008). Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women. American Journal of Geriatric Psychiatry, 16, 272-282.

Ahles, T. A., Saykin, A. J., McDonald, B. C., Furstenberg, C. T., Cole, B. F., Hanscom, B. S., Mulrooney, T. J., Schwartz, G. N., Kaufman, P. A. (2008). Cognitive function in breast cancer patients prior to adjuvant treatment. Breast Cancer Research and Treatment, 110, 143-152.

McAllister, T. W., Flashman, L. A., Rhodes, C. H., Tyler, A. L., Moore, J. H., Saykin, A. J., McDonald, B. C., Tosteson, T. D., & Tsongalis, G. J. (2008). Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: A replication and extension study. Brain Injury, 22, 705-714.

Risacher, S. L., Saykin, A. J., West, J. D., Shen, L., Firpi, H. A., McDonald, B. C., and the Alzheimer's Disease Neuroimaging Initiative (ADNI). (2009). Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Current Alzheimer Research, 6, 347-361.

Golomb, M. R., McDonald, B. C., Warden, S. J., Yonkman, J., Saykin, A. J., Shirley, B., Huber, M., Rabin, B., Abdelbaky, M., Nwosu, M. E., Barkat-Masih, M., Burdea, G. C. (2010). In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy. Archives of Physical Medicine and Rehabilitation, 91, 1-8.e1.

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