Anthony J. Baucum II, Ph.D.
Assistant Professor of Biology
Ph.D., Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT (2004)
Functional role of cell-specific synaptic protein complexes in altered dopaminergic states.
The goal of the Baucum laboratory is to understand the functional organization of synaptic proteins in cell type-specific dendritic spines. Moreover, we want to determine how changes in dopamine signaling, either in animal models of Parkinson Disease (decreased dopamine) or following chronic treatment with drugs of abuse (increased dopamine) modulate synaptic organization in specific cell types. Specifically, we are evaluating the association of the dendritic-spine protein, spinophilin, with multiple other synaptic proteins. Spinophilin binds to F-actin and protein phosphatase 1 to modulate actin dynamics as well as the phosphorylation status of multiple synaptic targets. We are interested in identifying novel spinophilin associated proteins, identifying cell-specific differences in the spinophilin interactome, and determining cell-specific functional roles of spinophilin. Together, these data will enhance our understanding of cell-specific synaptic connectivity and identify putative therapeutic pathways that may be relevant in treating PD and drug addiction.
- Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ 2nd, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ. CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. Nat Neurosci. 2013 Apr;16(4):456-63.
- Baucum AJ 2nd, Brown AM, Colbran RJ. Differential association of postsynaptic signaling complexes in striatum and hippocampus. J Neurochem. 2013 Feb;124(4):490-501. PMID: 23173822.
- Baucum AJ 2nd, Strack S, Colbran RJ. Age-dependent targeting of protein phoshpatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum. PLoS One. 2012;7(2):e31554. PMID: 22348105.
- Anthony J. Baucum II, Nidhi Jalan-Sakrikar, Yuxia Jiao, Richard M. Gustin, Leigh C. Carmody, David L. Tabb, Amy-Joan L. Ham, Roger J. Colbran. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol. Cell. Proteomics. 2010 Jun 9(6):1243-59. PMID: 20124353.