Liana G. Apostolova, M.D., MSc, FAAN

Barbara and Peer Baekgaaard Professor, Alzheimer's Disease Research
Professor, Neurology, Radiology, Medical and Molecular Genetics
Indiana University School of Medicine
Indiana Alzheimer's Disease Center

M.S., Clinical Research, University of California, Los Angeles (2010)
M.D. (Summa-cum-laude), Medicine, Medical Unversity, Sofia, Bulgaria (1998)

Title and paragraph describing research:
Liana G. Apostolova, MD, MSc, FAAN joined the IU School of Medicine as a the Barbara and Peer Baekgaard Professor in Alzheimer’s Disease Research, Professor of Neurology, Radiology, Medical and Molecular Genetics in June of 2015. She graduated Summa cum Laude from the Medical University, Sofia, Bulgaria in 1998, and completed Neurology residency training at University of Iowa and Dementia fellowship at UCLA. Dr. Apostolova is a prolific researcher with over 80 original peer-reviewed publications. Her research focuses on the prodromal and presymptomatic stages of Alzheimer's Disease and on the development and validation of sensitive imaging and genetic biomarkers for Alzheimer's disease and other dementing disorders. She is the Founding Director of the UCLA-Easton Neuroimaging Laboratory. Dr. Apostolova is former recipient of the highly prestigious K23 Beeson Career Development Award as well as several grants form the NIH, private foundations and industry. She was awarded the 2010 American Academy of Neurology Research Award in Geriatric Neurology, the 2010 American Federation for Aging Research GE-Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research and the 2007 Turken Research Award. Dr. Apostolova has served as a research mentor to over 50 undergraduate, 18 graduate and 3 post-graduate students. She serves as a Senior Associate Editor for the Alzheimer’s and Dementia: Disease Assessment and Monitoring journal and as the Chair of the Neuroimaging Professional Interest Area of the Alzheimer’s Association.

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Selected Publications:

1)   Andrawis J, Hwang KS, Green AE, Kotlerman J, Elashoff D, Morra JH, Cummings JL, Toga AW, Thompson PM, Apostolova LG. Effects of maternal history of Alzheimer’s disease on hippocampal atrophy, Neurobiol Aging, 2012, 33; 856-866; e-pub; PMC3010297 

2)    Apostolova LG, Alves G, Hwang KS, Babakchanian S, Bronnick K, Larsen JP, Thompson PM, Chou Y, Tysnes OB, Beyer M. Hippocampal and ventricular changes in Parkinson’s disease subjects with mild cognitive impairment. Neurobiol Aging, 2012; 33 (2012): 2113-2124. PMCID 4077346

3)    Apostolova LG, Babakchanian S, Hwang KS, Green AE, Zlatev D, Chou YY, Jack CR, Petersen RC, Aisen PS, Cummings JL, Toga AW, Thompson PM. Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI Donepezil/Vitamin E study. ADAD 2013; 27(2): 174-181. PMC3662002.

4)    Beyer M, Alves G, Hwang KS, Babakchanian S, Bronnick K, Chou Y, Larsen JP, Mulugeta E, Thompson PM, Tysnes OB, Apostolova LG. Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease.  Mov Dis, 2013: 28(3): 302-310. PMC3608817

5)   Lee GJ, Lu PH, Medina L, Rodrigues Y, Melchor S, Coppola G, Braskie MN, Apostolova LG, Leow A, Thompson PM, Ringman JR. Regional brain volume differences in symptomatic and presymptomatic and carriers of familial AD mutations. JNNP, 2013: 84(2): 154-162. PMC3779052

6)    Hwang KH, Beyer MK, Green AE, Thompson PM, Janvin C, Larsen JP, Cummings JL, Aarsland D, Apostolova LG. Mapping Cortical Atrophy in Parkinson’s Disease Patients with Cognitive Impairment and Dementia. Dementia and Geriatric Cognitive Disorders, 2013: 3(1): 69-76. PMC4018208

7)   Kohannim O, Hua X, Rajagopalan P, Hibar DP, Jahanshad N, Grill J, Apostolova LG, Toga AW, Jack CR, Weiner MW, Thompson PM. Multilocus genetic profiling to empower drug trials and predict brain atrophy. Neuroimage Clinical, 2013: 2: 827-835. PMC 3777716

8)    Apostolova LG. “Generation Next” in Alzheimer’s Disease Genetic Studies. Invited Editorial. Nat Rev Neurol. 2013; 9 (8): 422-423. PMC4041698

9)   Thompson PM, Stein JL, Medland SE, Hibar DP, Vasques AA, Renteria M, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, et al. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior 2014; 8(2): 153-82. PMC4008818

10) Apostolova LG, Hwang KS, Kohannim O, Avila D, Jack CR, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer’s disease. Neuroimage Clinical 2014,4:461-472. PMC3952354

11) Apostolova LG, Di LJ, Elashoff D, Tseng CH, Fairbanks L, Cummings JL. Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer’s disease. Dem Geriatr Cog Dis 2014; 37:315-325. PMC4057985.

12) Boccardi M, Bocchetta M, Apostolova LG, et al. Establishing MRI Orientation for the EADC-ADNI manual hippocampal segmentation protocol. J Neuroimaging 2014; 24 (5):509-14; doi: 10.1111/jon.12065. PMC pending.

13) Teng E, Chow N, Hwang KS, Teng E, Thompson PM, Gylys K, Cole G, Jack CR, Shaw L, Trojanowski J, Soares H, Weiner M, Apostolova LG. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Dem Geriatr Cog Disord 2014 Dec 24;39(3-4):154-166. PMC4323932

14) Bocchetta M, Boccardi M, Ganzola R, Apostolova LG, et al. Harmonized benchmark labels of the hippocampus on MR: the EADC-ADNI project. Alzheimer’s and Dementia, Alzheimer’s and Dementia 2015, 11(2):151-160, DOI:10.1016/j.jalz.2013.12.019. PMC43233932

15) Boccardi M, Bocchetta M, Apostolova LG, et al. Delphi definition of the EADC-ADNI Harmonized Protocol for Hippocampal Segmentation on magnetic resonance. Alzheimer’s and Dementia 2015, 11(2):126-138, DOI: 10.1016/j.jalz.2014.02.009. PMC4419736

16) Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, et al. The EADC-ADNI Harmonized Protocol for Hippocampal Segmentation on Magnetic Resonance: Evidence of Validity. Alzheimer’s and Dementia 2015, 11(2): 111-125, DOI: 10.1016/j.jalz.2014.05.1756. PMC4422168

17) Apostolova LG, Hwang KS, Avila D, Elashoff D, Kohannim O, Teng E, Sokolow S, Jack CR, Jagust WJ, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. Brain amyloidosis can be ascertained from cognitive, imaging and peripheral blood protein measures. Neurology 2015,84 (7):729-737, DOI: 10.1212/WNL.0000000000001231. PMC4336101

18) Chow N, Hwang KS, Hurtz S, Green AE, Somme JH, Thompson PM, Elashoff DA, Jack CR, Weiner M, Apostolova LG. Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer’s Disease Neuroimaging Initiative. AJNR 2015, 36(4):653-640, DOI: 10.3174/ajnr.A4228

19)Apostolova LG, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, Honarpisheh H, Blanken AE, Brook J, Tung S, Ng D, Alger JA, Vinters HV, Bocchetta M, Duvernoy H, Jack CR, Frisoni GB. Relationship Between Hippocampal Atrophy and Neuropathology Markers: a 7T MRI Study. Alzheimer’s and Dementia 2015, 11(2):139-150, DOI: 10.1016/j.jalz.2015.01.001. PMC4348340

20) Duchesne S, Valdivia F, Robitaille N, Mouiha A, Valdivia A, Bocchetta M, Apostolova LG, Ganzola R, Preboske G, Wolf D, Boccardi M, Jack CR, Frizoni GB. Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project. Alzheimer’s and Dementia 2015, 11(2):161-174, DOI: 10.1016/j.jalz.2015.01.002

21) Hwang KS, Lazaris A, Eastman J, Teng E, Thompson PM, Gylys K, Cole G, Apostolova LG. Plasma BDNF levels associate with Pittsburgh compound B binding in the brain. DADM 2015, 1, 187-193. PMC4507280

22) Lazaris A, Hwang KS, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin A, Shaw L, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG. Alzheimer’s Disease Risk Genes Modulate the Relationship Between Plasma ApoE and Pittsburgh Compound B (PiB) Binding in the Brain. Neurology Genetics 2015,1;3:e22.

23) Madhavan A, Josephs KA, Schwarz CG, Duffy JR, Strand EA, Machulda MM, Drubach DA, Kantarci K, Przybelski SA, Reid RI, Senjem ML, Gunter JL, Apostolova LG, Lowe VJ, Petersen RC, Jack CR, Whitwell JL. Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease: a diffusion tensor imaging study, J Alz Dis, 49 (3):633-43.

24) Ramirez LM, Goukasian N, Porat S, Hwang KS, Eastman JA, Hurtz S, Wang B, Vang N, Sears R, Klein E, Coppola G, Apostolova LG. Common Variants in ABCA7 and MSA46A are Associated with Cortical and Hippocampal Atrophy. Neurobiol of Aging, 39:82-89.

25) Clark DG, McLaughlin P, Woo E, Hwang KH, Hurtz S, Ramirez L, Eastman J, Dukes RM, Kapur P, DeRamus TP, Apostolova LG. Novel verbal fluency scores and structural brain imaging for prediction of cognitive outcome in mild cognitive impairment, DADM, e-pub ahead of print.

26) Rattanabannakit C, Risacher SL, Gao S, Lane KA, Brown SABC, Unverzagt FW, Apostolova LG, Saykin AJ, Farlow MR. The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests, JAD, e-pub ahead of print.

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