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Bernardino Ghetti, M.D.

Distinguished Professor, Pathology
Chancellor's Professor, IUPUI
Core Leader, Indiana Alzheimer Disease Center, Neuropathology Core

Education/Training:
M.D., University of Pisa,Italy (1966)

Research in Hereditary Pre-senile Dementias.
During the past 39 years, Dr. Ghetti has led groundbreaking investigations of neurodegenerative diseases in humans and animal models. He has had a particular interest in diseases associated with mutations in genes that encode proteins that are essential for neuronal function. These mutations induce the protein to go through conformational changes and hence the degenerative process. Dr. Ghetti's approach has been to use the structural abnormality observed in brain to not only provide a complete neuropathological diagnosis, but also to guide the molecular neuropathology laboratory toward discovering the etiological basis of disease. He has studied neurological mutant mice since 1976 and transgenic mice created with mutations in APP, PRNP, MAPT, and other genes causing neurodegeneration since 1997. In 1999, he was awarded the Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases from the American Academy of Neurology.

Selected Publications:

  1. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM: Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet. 17:263-264, 1997; PMID: 9354781.

  2. Chiesa R, Piccardo P, Ghetti B, Harris DA: Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. Neuron 21:1339-1351, 1998; PMID: 9883727.

  3. Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M: Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 22:9340-9351, 2002; PMID: 12417659.

  4. Vidal R, Sammeta N, Garringer HJ, Sambamurti K, Miravalle L, Lamb BT, Ghetti B: The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. FASEB J. 26:2899-2910, 2012. doi: 10.1096/fj.12-205542. Epub 2012 Mar 29.

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