Shannon L. Risacher, Ph.D.
Assistant Research Professor of Radiology and Imaging Sciences
BS, Psychology, IUPUI (2002-2006)
PhD, Medical Neuroscience, Indiana University School of Medicine (2006-2011)
Post-doc, Indiana University School of Medicine (2012-2014)
Imaging and Sensory Biomarkers for Alzheimer’s disease.
My main research interests involve evaluating imaging and non-imaging biomarkers of Alzheimer’s disease for utility in early detection and diagnosis. In particular, I am interested in evaluating which biomarkers are most sensitive in the earliest stages of disease, both for detecting pathophysiological changes and for predicting future clinical outcomes. I am primarily focused on structural, functional and molecular imaging biomarkers of AD, but have additional interest in novel biomarkers such as sensory and perceptual tests. Specifically, I am investigating tests of vision, smell, and hearing as potential biomarkers of dementia. Finally, I am interested in the impact of genetic variations in the development of dementia and the molecular changes associated with cognitive decline.
Risacher SL, Kim S, Nho K, Foroud T, Shen L, Petersen RC, Jack CR Jr., Beckett LA, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (in press). APOE effect on Alzheimer’s biomarkers in older adults with significant memory concern. Alzheimer’s and Dementia.
Deters KD, Risacher SL, Farlow MR, Unverzagt FW, Kareken DA, Hutchins GD, Yoder KK, Murrell JR, Spina S, Epperson F, Gao S, Saykin AJ, Ghetti B. Cerebral hypometabolism and grey matter density in MAPT intron 10+3 mutation carriers. American Journal of Neurodegenerative Disease, 2014 Dec 5; 3(3): 103-114.
Nudelman KNH, Risacher SL, West JD, McDonald BC, Gao S, Saykin AJ, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (2014). Association of cancer history with Alzheimer’s disease onset and structural brain changes. Frontiers in Physiology – Systems Biology, 2014 Oct 31; 5(423): 1-12.
Risacher SL, Saykin AJ (2013). Neuroimaging biomarkers of neurodegenerative diseases and dementia. Seminars in Neurology, 33(4): 386-416.
Risacher SL, Wang Y, Wishart HA, Rabin LA, Flashman LA, McDonald BC, West JD, Santulli RB, Saykin AJ (2013). Cholinergic enhancement of brain activation in mild cognitive impairment during episodic memory encoding. Frontiers in Psychiatry, 4(105): 1-20.
Risacher SL, Kim S, Shen L, Nho K, Foroud T, Green RC, Petersen RC, Jack CR Jr., Aisen PA, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (2013). The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI). Frontiers in Aging Neuroscience, 5(11): 1-12.
Risacher SL and Saykin AJ (2013). Neuroimaging and Other Biomarkers of Alzheimer’s Disease: The Changing Landscape of Early Detection. Annual Review of Clinical Psychology, 9: 621-648.
Risacher SL, WuDunn D, Pepin SM, MaGee TR, McDonald BC, Flashman LA, Wishart HA, Pixley HS, Rabin LA, Paré N, Englert JJ, Schwartz E, Curtain JR, West JD, O’Neill DP, Santulli RB, Newman RW, Saykin AJ (2013). Visual contrast sensitivity in AD, MCI, and older adults with cognitive complaints. Neurobiology of Aging, 34(4): 1133-44.