Nicholas J. Grahame, Ph.D.
Associate Professor, Psychology
B.A., Biopsychology, Vassar College, Poughkeepsie, NY (1987)
M.A., Psychology (Psychobiology), State University of New York at Binghamton (1990)
Ph.D., Psychology (Neuroscience), State University of New York at Binghamton (1992)
Area of Specialization: Behavioral Genetics, Behavioral Pharmacology.
"My laboratory focuses on the behavioral genetics of alcohol seeking behavior through research on behavioral markers that characterize differences in the likelihood that animal models will seek the pharmacologic effects of alcohol. We also assess neural circuits underlying how genes and environment interact in producing alcohol-related behaviors. Using these animal models, our ultimate goal is to find better treatments for alcoholism based on the latest understanding of the behavioral and genetic mechanisms that lie at the heart of alcoholism."
O'Tousa D.S., Warnock K.T., Matson L.M., Namjoshi O.A., Linn M.V., Tiruveedhula V.V., Halcomb M.E., Cook J., Grahame N.J., June H.L.. (2015). Triple monoamine uptake inhibitors demonstrate a pharmacologic association between excessive drinking and impulsivity in High Alcohol Preferring (HAP) mice. Addiction Biology, 20, 236-247. PMC 3984927.
Matson, L.M., Kasten C., Boehm S., and Grahame N.J. (2014). Selectively bred crossed High Alcohol Preferring mice drink to intoxication and develop functional tolerance, but not locomotor sensitization during free-choice ethanol access. Alcoholism:Clinical and Experimental Research, 38, 267-74. PMC: 3844084.
O’Tousa D.S. and Grahame, N.J. (2014). Habit formation: Implications for alcoholism research. Alcohol, 48, 327-335. PMC: 4096986.
Halcomb M.E., Gould T.D., and Grahame N.J. (2013). Lithium, but not Valproate, Reduces Impulsive Choice in the Delay Discounting Task in Mice. Neuropsychopharmacology, 38, 1937-1944. PMC 3746699.
Matson, L.M. and Grahame, N.J. (2013). Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high-alcohol-preferring mice. Addiction Biology, 18, 921-929. PMC 4259254.