Ann Kosobud, Ph.D.

Associate Scientist of Neurology

Ph.D., Biological Psychology, Oregon Health Sciences University (1988)

Research Statement:
The primary aim of my research has been to understand the neural mechanisms underlying addictive behavior (drug seeking and taking), to aid development of treatments.  I have pursued this interest using a variety of research approaches, including genetic selection studies in mice, single neuron recording in awake, behaving rats, studies of the circadian entrainment properties of drugs of abuse, and most recently, laboratory studies of human alcohol intake using iv infusion of alcohol solutions. 

Selected References:

  1. Kosobud, A. and Crabbe, J.C. (1986) Ethanol withdrawal in mice bred to be genetically prone (WSP) or resistant (WSR) to ethanol withdrawal seizures.  Journal of Pharmacology and Experimental Therapeutics 238: 170-177.

  2. Crabbe, J.C., and Kosobud, A. (1986) Sensitivity and tolerance to ethanol in mice bred to be genetically prone (WSP) or resistant (WSR) to ethanol withdrawal seizures.  Journal of Pharmacology and Experimental Therapeutics 239: 327-333.

  3. Kosobud, A., Bodor, A.S. and Crabbe, J.C.  (1988)  Voluntary consumption of ethanol in WSP, WSC and WSR selectively bred mouse lines.  Pharmacology, Biochemistry and Behavior 29:  601-607.

  4. Kosobud, A.E. and Crabbe, J.C.  (1990)  Genetic correlations among inbred strain sensitivities to convulsions induced by nine convulsant drugs.  Brain Research 526: 8-16.

  5. Kosobud, A.E., Cross, S.J. and Crabbe, J.C.  (1992)  Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice.  Brain Research, 592: 122-128.

  6. Kosobud, A.E. and Crabbe, J.C.  (1993)  Sensitivity to N-methyl-D-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures.  Brain Research, 610: 176-179.

  7. Kosobud, A.E.K.,  Harris, G.C. and Chapin, J.K.  (1994)  Behavioral associations of neuronal activity in the ventral tegmental area of the rat.  The Journal of Neuroscience, 14:  7117-7129.

  8. Kosobud, A.E.K., Pecoraro, N.C., Rebec, G.V. and Timberlake, W.  (1998) Circadian activity precedes daily methamphetamine injections in the rat.  Neuroscience Letters, 250: 99-102.

  9. Kosobud, A.E.K., Gillman, A.G., Leffel, J.E. II, Pecoraro, N.C., Rebec, G.V., and Timberlake, W.  (2007)  Drugs of abuse can entrain circadian rhythms.  ScientificWorldJournal. 7,203-212.

  10. Gillman, A.G., Leffel, J.K.II, Kosobud, A.E.K., and Timberlake, W.  (2009) Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals.  Behav. Brain Res., 205(1), 102-114.

  11. Plawecki MH. Wetherill L. Vitvitskiy V. Kosobud A. Zimmermann US. Edenberg HJ. O'Connor S.   Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study. Alcoholism: Clinical & Experimental Research. 37 Suppl 1:E152-60, 2013 Jan.

  12. Gillman, A.G., Leffel, J.K.II, Kosobud, A.E.K., and Timberlake, W. (2013) Behavioral characteristics and pharmacological manipulations of a nicotine-entrainable circadian oscillator. Chronobiol Int. 30(7), 855-869. doi: 10.3109/07420528.2013.782314. Epub 2013 May 22.

  13. Windisch KA, Kosobud AEK, Czachowski CL (2014) Intravenous alcohol self-administration in the P rat.  Alcohol, Aug;48(5):419-25. doi: 10.1016/j.alcohol.2013.12.007. Epub 2014 Apr 21. PubMed PMID: 24835637; PubMed Central PMCID: PMC4096581.

  14. Kosobud, A.E.K., Wetherill, L., Plawecki, M.H., Kareken, D.A., Liang, T., Nurnberger, J.L., Windisch, K., Xuei, X., Edenberg, H.J., Foroud, T.M., O’Connor, S.J. (2015) Adaptation of subjective responses to alcohol is affected by an interaction of GABGA2 genotype and recent drinking.  Alcohol Clin Exp Res, Jul;39(7):1148-57. doi: 10.1111/acer.12749. Epub 2015 Jun 19. PubMed PMID: 26087834; PubMed Central PMCID: PMC4490958.

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