Scott A. Shapiro, M.D.

Professor and Chief of Neurosurgery, Indiana University School of Medicine (IUSM)
Robert L. Campbell Professor of Neurological Surgery, IUSM Department of Neurological Surgery
Director, Neurosurgery Residency Program, IUSM

MD, Indiana University (1999)

Cellular, biochemical, and surgical interventions for brain & spinal cord injuries.
My clinical expertise includes tumors of the brain and pituitary, aneurysms and arteriovenous malformations, carpal tunnel and ulnar nerve entrapments, cervical thoracic and lumbar spine (minimally invasive and complex instrumentation), and cranial and spinal trauma. Over the past 2 decades, I have explored cellular, biochemical, and surgical interventions to improve postinjury outcomes for patients who have endured damage to the brain or spinal cord.

I am currently collaborating with Nicholas Barbaro, Richard Rodgers, and Eric Horn to develop a clinical trial for transplanting human oligodendrocyte progenitor cells in patients with spinal cord injury (SCI). With Riyi Shi, PhD, of Purdue, I am involved in SCI research aimed at identifying therapies that will significantly enhance structural and functional recovery.

Selected Publications:
Journal Articles

Shapiro S, Kubek M, Daly E, Siemers E, et al. Quantification of thyrotropin releasing hormone and serotonin content changes following graded spinal cord injury. J Surgical Research 1995;59:393-398. [PMID: 7643599]

Shapiro S. Neurotransmission of serotonergic, noradrenergic, glutamatergic, glycinergic and GABA-ergic neurons in the normal and injured spinal cord. Neurosurgery. 1997;40:168-177. [PMID: 8971839]

Tator CH, Fehlings MG, Thorpe K, Taylor W, [and Participants]. Current use and timing of spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study. J Neurosurgery 1999;91(Suppl 1):12-18. [PMID: 10419357]

Shapiro S, Abel T, Rodgers RB. Traumatic thoracic spinal fracture dislocation with minimal or no cord injury. J Neurosurgery 2002 Apr; 96(Suppl 3):333-337. [PMID: 11990843]

Laverty P, Leskovar A, Breur G, Coates J, Bergman R, Widmer W, Toombs J, Shapiro S, Borgens R. A preliminary study of intravenous surfactants in paraplegic dogs: Polymer therapy in canine clinical SCI. J Neurotrauma 2004;21(12):1767-1777. [PMID: 15684768]

Shapiro S, Borgens R, Pascuzzi R, Roos K, Groff M, Purvines S, Rodgers RB, Hagy S, Nelson P. Oscillating field stimulation for complete spinal cord injury in humans: A phase 1 trial. J Neurosurgery Spine 102(1):3-10, 2005. [PMID: 15658119]

Nehrt A, Rodgers R, Shapiro S, Borgens R, Shi R. The critical role of voltage-dependent calcium channel in axonal repair following mechanical trauma. Neuroscience 146(4):1504-1512, 2007. [PMID: 17448606]

Bohnert D, Purvines S, Shapiro S, Borgens R. Simultaneous application of two neurotrophic factors after spinal cord injury. J Neurotrauma 2007;24:846-851. [PMID: 17518539]

Smucker P, Hekmatyar SK, Bansal N, Rodgers RB, Shapiro SA, Borgens RB. Intravenous polyethylene glycol successfully treats severe acceleration-induced brain injury in rats as assessed by magnetic resonance imaging. Neurosurgery 64(5):984-990, 2009. [PMID: 19404158]

Shapiro SA. Review of oscillating field stimulation to treat human spinal cord injury. World Neurosurgery 2014 May-Jun;81(5-6):830-5. doi: 10.1016/j.wneu.2012.11.039. Epub 2012 Nov 14. [PMID: 23159651]

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