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Nicholas M. Barbaro, M.D., F.A.C.S.

Betsey Barton Professor and Chair of Neurosurgery, Indiana University School of Medicine
Medical Director, IU Health Neurosciences Center, Indianapolis, IN
Fellow, American College of Surgeons

Education/Training:
MD, University of Pittsburgh, Pittsburgh, PA (1979)

Neurosurgery, epilepsy, nerve injury, and pain.
My clinical specialty is Neurosurgery, with emphasis on nerve injury, pain, and epilepsy. My expertise within that specialty is pain mechanisms, epilepsy mechanisms, radiation injury, and nerve regeneration. Research. In the past 20 years, I have held numerous positions as principal investigator or co-principal investigator on research projects funded by CDC, FDA, NIH, NINCDS, and Elekta Corporation (industry). I hold active grants for clinical trials that investigate surgical therapies in patients with temporal lobe epilepsy (NIH), and long-term treatment of epilepsy patients with an implanted neurostimulator (Neuropace). Publications. I have published over 150 articles in peer-reviewed journals, including American Journal of Neuroradiology, Annals of Neurology, Epilespia, Journal of Cognitive Neuroscience, Journal of Neurosurgery, Neurology, and Neurosurgery, among others.

I have established collaborations with Kathryn Jones on peripheral nerve regeneration, with Xiaoming Jin on post-traumatic epilepsy, with Xiao-Ming Xu on spinal cord injury, and with Eric Horn, Richard Rodgers, and Scott Shapiro on clinical trials of spinal cord injury and traumatic brain injury.

Selected Publications:

Books

Tubbs RS, Rizk E, Shoja MM, Loukas M, Barbaro N, Spinner RJ, eds. Nerves and Nerve Injuries,
Volume 1: History, Embryology, Anatomy, Imaging, and Diagnosis.
London, UK: Elsevier; 2015.

Tubbs RS, Rizk E, Shoja MM, Loukas M, Barbaro N, Spinner RJ, eds. Nerves and Nerve Injuries,
Volume 2: Pain, Treatment, Injury, Disease, and Future Directions.
London, UK: Academic Press/Elsevier; 2015.

Peer-Reviewed Journal Articles:

Edwards E, Nagarajan SS, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT Spatiotemporal imaging of cortical activation during verb generation and picture naming. Neuroimage 50(1): 291-301, 2010. [PMID: 20026224]

Chang EF, Christie C, Sullivan JE, Garcia PA, Tihan T, Gupta N, Berger MS, Barbaro NM: Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. J Neurosurg Pediatr 5(1): 123-130, 2010. [PMID: 20043747]

Chang EF, Quigg M, Oh MC, Dillon WP, Ward MM, Laxer KD, Broshek DK, Barbaro NM, Epilepsy Radiosurgery Study Group: Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology 74(2): 165-172, 2010. [PMID: 20065252]

Fisher R, (et al); the SANTE Study Group: Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia 51(5): 899-908, 2010.

Chang EF, Barbaro NM: Nonresective epilepsy surgery. Epilepsia Feb; 51 Suppl:87-89, 2010. [PMID: 20331727]

Chang EF, Rieger JW, Johnson K, Berger MS, Barbaro NM, Knight RT: Categorical speech representation in human superior temporal gyrus. Nat Neurosci Nov; 13(11): 1428-1432, 2010. [PMID: 20890293]

Englot DJ, Berger MS, Barbaro NM, Chang EF: Predictors of seizure freedom after resection of supratentorial low-grade gliomas. J Neurosurg Aug;115(2): 240-244, 2011. [PMID: 21529134]

Loring DW, Lowenstein DH, Barbaro NM, Fureman BE, Odenkirchen J, Jacobs MP, Austin JK, Dlugos DJ, French JA, Gaillard WD, Hermann BP, Hesdorffer DC, Roper SN, Van Cott, AC, Grinnon S, Stout A: Common data elements in epilepsy research: Development and implementation of the NINDS epilepsy CDE project. Epilepsia Jun; 52(6): 1186-1191, 2011. [PMID: 21426327]

Quigg M, Broshek DK, Barbaro NM, Ward MM, Laxer KD, Yan G, Lamborn K; Radiosurgery Study Group
Neuropsychological outcomes after gamma knife radiosurgery for mesial temporal lobe epilepsy: A prospective multicenter study. Epilepsia May; 52(5): 909-916, 2011. [PMID: 21426323]

Chang EF, Wang DD, Perry DW, Barbaro NM, Berger MS: Homotopic organization of essential language sites in right and bilateral cerebral hemispheric dominance. J Neurosurg Apr; 114(4): 893-902, 2011.
[PMID: 21235314]

Yang I, Chang EF, Han SJ, Barry JJ, Fang S, Tihan T, Barbaro NM, Parsa AT: Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes. J Clin Neurosci Jan; 18(1): 29-33, 2011. [PMID: 20961765]

Flinker A, Chang EF, Barbaro NM, Berger MS, Knight RT: Sub-centimeter language organization in the human temporal lobe. Brain Language, Jun; 117(3): 103-109, 2011. [PMID: 20961611]

Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT: Cortical spatio-temporal dynamics underlying phonological target detection in humans. J Cogn Neurosci Jun; 23(6): 1437-1446, 2011. [PMID: 20465359]

Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM: Predictors of seizure freedom after surgery for malformations of cortical development. Ann Neurol Jul;70(1): 151-162, 2011. [PMID: 21761443]

Chang EF, Barbaro NM: Epilepsy surgery: the emerging field of neuromodulation. Neurosurg Clin N Am 2011 Oct;22(4): ix-x, 2011. [PMID: 21939840]

Englot DJ, Berger MS, Barbaro NM, Chang EF: Factors associated with seizure freedom in the surgical resection of glioneuronal tumors. Epilepsia Jan;53(1): 51-57, 2012. [PMID: 21933181]

Englot DJ, Han SJ, Berger MS, Barbaro NM, Chang EF: Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumors. Neurosurgery Apr;70(4): 921-928; discussion 928, 2012. [PMID: 21997540]

Quigg M, Rolston J, Barbaro NM: Radiosurgery for epilepsy: clinical experience and potential antiepileptic mechanisms. Epilepsia Jan;53(1): 7-15, 2012. [PMID: 22191545]

Rowland NC, Englot DJ, Cage TA, Sughrue ME, Barbaro NM, Chang EF: A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg May;116(5): 1035-1041, 2012. [PMID: 22324422]

Southwell DG, Garcia PA, Berger MS, Barbaro NM, Chang EF: Long-term seizure control outcomes after resection of gangliogliomas. Neurosurgery Jun;70(6): 1406-1414, 2012. [PMID: 22353798]

Englot DJ, Ouyang D, Garcia PA, Barbaro NM, Chang EF: Epilepsy surgery trends in the United States, 1990-2008. Neurology Apr 17;78(16): 1200-1206, 2012. [PMID: 22442428]

Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF: Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg Feb 118(2):337-344, 2013. [PMID: 23216463]

Hensley-Judge H, Quigg M, Barbaro NM, Newman SA, Ward MM, Chang EF, Broshek DK, Lamborn KR, Laxer KD, Garcia P, Heck CN, Kondziolka D, Beach R, Salanova V, Goodman R. Visual field defects after radiosurgery for mesial temporal lobe epilepsy. Epilepsia. May 10. doi: 10.1111/epi.12215. Epub ahead of print. [PMID: 23663063]

Cheng JS, Lim DA, Chang EF, Barbaro NM. A review of percutaneous treatments for trigeminal neuralgia. Neurosurgery. 2014 Mar;10 Suppl 1:25-33. doi: 10.1227/NEU.00000000000001687. [PMID: 24064481]

Salanova V, Witt T, Worth R, Henry TR, Gross RE, Nazzaro JM, Labar D, Sperling MR, Sharan A, Sandok E, Handforth A, Stern JM, Chung S, Henderson JM, French J, Baltuch G, Rosenfeld WE, Garcia P, Barbaro NM, Fountain NB, Elias WJ, Goodman RR, Pollard JR, Tröster AI, Irwin CP, Lambrecht K, Graves N, Fisher R; SANTE Study Group. Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy. Neurology. 2015 Mar 10;84(10):1017-25. Epub 2015 Feb 6. [PMID: 25663221]

Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL. SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Disease 2015 May; 77:127-40. doi: 10.1016/j.nbd.2015.02.025. Epub 2015 Mar 10. [PMID: 25766675]

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