Eric Horn, M.D., Ph.D.
Director of Spinal Neurosurgery, Department of Neurological Surgery, Indiana University
Associate Professor, Department of Neurological Surgery, Indiana University
Adjunct Graduate Faculty, Department of Biomedical Engineering, Purdue University
M.D. University of Illinois (2000)
Ph.D. University of Illinois (2000)
Spinal Neurosurgery Fellowship, Barrow Neurological Institute (2003)
Spinal Trauma Fellowship, Barrow Neurological Institute (2005)
Neurosurgery Residency, Barrow Neurological Institute (2007)
Clinical Translation of Experimental Models of Spinal Cord Injury.
In collaboration with the Spinal Cord and Brain Injury Research Group at Indiana University, we are in the unique position of maintaining a pathway to directly translate the discoveries made in the laboratory into clinical trials. This is truly a bench-to-bedside approach that allows us to advance the treatments of spinal cord injury.
We care for patients with a myriad of acute and subacute spinal cord injuries throughout all of Indiana and the Midwest. In order to treat every type of spinal cord injury, we utilize the latest advancements in surgical technology, including computer-guided neuro-navigation and complex spinal stabilization instrumentation. We also provide cutting edge post-operative care in the neuro-intensive care units and neuro-rehabilitation. This clinical care is coupled with a dedicated clinical research support staff to allows us to efficiently perform clinical trials of treatments for patients with spinal cord injuries.
We are the only site in Indiana that participated in the international clinical trial for evaluating the safety and efficacy of a pharmaceutical treatment for acute spinal cord injury. The study was sponsored by Asubio Pharmaceutical, which has developed the drug, SUN13837, a molecule similar to beta fibroblast growth factor (bFGF). This molecule has shown efficacy in treating paralysis in animal models, which led to the clinical trial. The study has completed and data are being analyzed.
To develop novel treatments for brain and spinal cord injuries within the IU School of Medicine, we are collaborating with Xiao-Ming Xu and other ISCBIRG scientists on lipidomics studies in patients with spinal cord injury. Another collaboration involves a clinical trial for transplanting human oligodendrocyte progenitor cells in patients with spinal cord injury. Going forward, we will assist in the design of experimental treatments for spinal cord injury in animal models that have the potential to be translated into clinical trials. We will also assist in the design and management of these clinical trials to determine the efficacy of these treatments for spinal cord injury in patients.
Recent Publications (2008–2015):
- Feiz-Erfan I, Spetzler RF, Horn EM, Porter RW, Beals SP, Lettieri SC Joganic EF, Demonte F. Proposed classification for the transbasal approach and its modifications. Skull Base 18(1):29-47, 2008. [PMID: 18592024]
- Bambakidis NC, Feiz-Erfan I, Horn EM, Gonzalez LF, Sonntag VKH, Baek S, Yuksel KZ, Brantley AGU, Crawford NR. Biomechanical comparison of occipito-atlantal screw fixation techniques. Journal of Neurosurgery Spine 8(2):143-152, 2008. [PMID: 18248286]
- Horn EM, Theodore N, Assina R, Spetzler RF, Sonntag VKH, Preul MC. The effects of intrathecal hypotension on tissue perfusion and pathophysiological outcome following acute spinal cord injury. Neurosurgical Focus 25(5):E12, 2008. [PMID: 18980472]
- Bambakidis NC, Horn EM, Nakaji P, Theodore N, Bless E, Dellovade T, Ma C, Wang X, Preul MC, Coons SW, Spetzler RF, Sonntag VKH. Endogenous stem cell proliferation is induced by intravenous hedgehog agonist administration after contusion injury in the adult rat spinal cord. Journal of Neurosurgery Spine 10:171-176, 2009. [PMID: 19278333]
- Horn EM, Reyes PM, Baek S, Senoglu M, Theodore N, Sonntag VKH, Crawford NR. Biomechanics of C7 transfacet screw fixation. Journal of Neurosurgery Spine 11:338-43, 2009. [PMID: 19769516]
- Lastfogel JF, Altstadt TJ, Rodgers RB, Horn EM. Sacral fractures following stand alone L5-S1 ALIF for isthmic spondylolisthesis. Journal of Neurosurgery Spine 13(2):288-93, 2010. [PMID: 20672968]
- Marshall AE, Martin SE, Agaram NP, Chen JH, Horn EM, A.C. Douglas-Akinwande and E.M. Hattab. A 61 year-old woman with osteomalacia and a thoracic spine lesion. Brain Pathology 20(2):499-502, 2010. [PMID: 20438469]
- Brennan RP, Altstadt TJ, Rodgers RB, Horn EM. Multi-level corpectomies and reconstruction via a single posterolateral approach. Journal of Clinical Neuroscience 17:1399-1404, 2010. [PMID: 20692172]
- Shaikh KA, Helbig GM, Shapiro SA, Shah MV, Khairi SA, Horn EM. Spinal surgery following organ transplantation. Journal of Neurosurgery Spine 14:779-784, 2011. [PMID: 21438655]
- Shaikh KA, Helbig GM, Horn EM. Outcomes of spine fusion following Autologous stem cell transplantation. Journal of Clinical Neuroscience 20(1):62-65, 2013. [PMID: 23036168]
- Puthenveetil PJ, Hattab EM, Peacock M, Horn EM. Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia. Journal of Clinical Neuroscience 20(8):1057-1061, 2013 [PMID: 23618679]
- Gianaris TJ, Helbig GM, Horn EM. Percutaneous pedicle screw placement with computer-navigated mapping in place of k-wires. Journal of Neurosurgery Spine 2013 Nov;19(5):608-613. [PMID:24010897]
- Patel NB, Dodd ZH, Voorhies J, Horn EM. Minimally invasive lateral transpsoas approach for spinal discitis and osteomyelitis. J Clin Neurosci 2015 Jul 22. pii: S0967-5868(15)00285-4. doi: 10.1016/ j.jocn.2015.03.061. Epub ahead of print. [PMID: 26209920]